Value of serum SDF-1a half-life in predicting postoperative recurrence and metastasis in patients of breast cancer
10.3760/cma.j.issn.1007-631X.2010.11.017
- VernacularTitle:趋化因子SDF-1a生物半衰期预测乳腺癌术后复发及转移
- Author:
Gaosong WU
;
Xiaopeng MA
;
Yanyan LIU
;
Jie WANG
;
Lili HUANG
;
Jie LIU
;
Yuping YIN
;
Jilin YI
;
Shengquan ZOU
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Half-life;
Chemotatic factors
- From:
Chinese Journal of General Surgery
2010;25(11):907-909
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the plasma level of SDF-1a in patients with breast cancer after modified radical mastectomy and chemotherapy, and to evaluate the value of serum SDF-1a half-life for predicting breast cancer recurrence and metastasis. The correlation of SDF-1 a half-life and breast cancer recurrence and metastasis after treatment were retrospectively analyzed. Methods Serum chemokine SDF-1a of 112 cases of breast cancer were detected before and after modified radical surgery, and 1 day beforeeach chemotherapy session. SDF-1a levels and the dynamic changes in the process were observed and calculated. Results In 85 cases with no recurrence and metastasis the plasma level of SDF-1 a decreased rapidly to normal level ,while that in 27 cases with recurrence and metastasis was on high level with the halflife of SDF-1a being longer than that in no recurrence group(P ＜0. 01 ). Taking SDF-1a half-life ≥14 d as cut off point to predict breast cancer recurrence and metastasis after treatment, the sensitivity is 81.5%,specificity is 70. 6 %, and accuracy is 73.2%. Conclusions Serum SDF-1a half-life is a valuable marker in predicting postoperative breast cancer recurrence and metastasis.
