Autologous peripheral hematopoietic stem cell transplantation in the treatment of adult dermatomyositis: a case report
- VernacularTitle:自体外周造血干细胞移植治疗成人皮肌炎一例
- Author:
Xia YU
;
Huaishan QI
;
Zhiyong LU
;
Hui LIANG
;
Zhirong YAO
- Publication Type:Journal Article
- Keywords:
Hematopoietic stem cell transplantation;
Dermatomyositis
- From:
Chinese Journal of Dermatology
2010;43(12):847-850
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy of autologous peripheral hematopoietic stem cell transplantation in the treatment of adult dermatomyositis. Methods A 21-year-old patient with dermatomyositis received autologous peripheral hematopoietic stem cell transplantation and was followed up for 6 years. Autologous peripheral hematopoietic stem cells were mobilized by recombinant human granulocyte colony stimulating factor (rhG-CSF) before the transplantation, and the conditioning regimens consisted of cyclophosphamide,methylprednisolone and cyclosporin. Rabbit anti-human T lymphocyte immunoglobulin began to be applied on day 3 after retransfer of stem cells. The improvement in symptoms, physical signs and biochemical indicators was observed, and hematopoietic restructuration and immunity resurrection were evaluated after the transplantation. Results After the transplantation, skin eruption greatly improved and gradually subsided. The muscle force of extremities restored from level Ⅳ before transplantation to level Ⅴ. The level of creatine kinase declined sharply after transplantation, but gradually returned to previous level. Leucocyte count began to decrease on the day of retransfer, and returned to the normal level on day 8. Immune function remained normal before and after the transplantation. Conclusion Autologous peripheral hematopoietic stem cell transplantation is an alternative treatment for severe and refractory dermatomyositis.
