Progress of the transcriptional regulation mechanism of Farnesoid X receptor in the pathogenesis of bile metabolic related diseases
10.3760/cma.j.issn.1673-4203.2010.11.019
- VernacularTitle:核受体FXR在胆汁代谢相关脏器疾病中的调控机制及研究进展
- Author:
Hanxiang ZHAN
;
Taiping ZHANG
;
Yupei ZHAO
- Publication Type:Journal Article
- Keywords:
Farnesoid X receptor;
Liver regeneration;
Primary hepatic carcinoma;
Intestinal barrier function;
Colonrectal cancer
- From:
International Journal of Surgery
2010;37(11):777-780
- CountryChina
- Language:Chinese
-
Abstract:
Farnesoid X receptor(FXR), a member of the metabolic nuclear receptor superfamily, plays key roles in maintaining bile acid and lipid homeostasis.FXR is highly expressed in the entero-hepatic system where it transcriptionally regulates bile acid metabolism, intestinal barrier function and liver regeneration, etc.Loss or down regulation of FXR expression can lead to a lot of diseases, such as cholecystolithiasis, biliary cirrhosis,primary hepatic carcinoma, colon carcinoma, etc.Activation of FXR may protect against or provide a pharmacological target for these diseases.
