Emerging roles of activating transcription factor 2 in cancer
10.3760/cma.j.issn.1673-422X.2010.11.001
- VernacularTitle:激活转录因子2及其在肿瘤中的研究进展
- Author:
Junfen XU
- Publication Type:Journal Article
- Keywords:
Activating transcription factor 2;
neoplasms
- From:
Journal of International Oncology
2010;37(11):803-806
- CountryChina
- Language:Chinese
-
Abstract:
The Activating Transcription Factor 2 (ATF2) mainly regulates gene transcriptions through mediating cellular response to environmental stimulus. Accumulating studies show that ATF2 is involved in tumorigenesis and tumor cell proliferation, differentiation , apoptosis , invasion and metastasis. Activation of ATF2 may promote tumor cells growth, however, there are several studies show that ATF2 might inhibit growth of tumor cell. Further understanding of the role for ATF2 in tumorigenesis might provide novel thinking pathways for tumor etiology and therapy.
