The study of serum TWEAK and survivn in rheumatoid arthritis
10.3760/cma.j.issn.1007-7480.2010.11.009
- VernacularTitle:类风湿关节炎患者血清中肿瘤坏死因子凋亡样微弱诱导剂和凋亡调节蛋白生存素水平的检测和意义
- Author:
Mei SHI
;
Weifeng SHI
;
Min WU
;
Rurong SUN
- Publication Type:Journal Article
- Keywords:
Arthritis,rheumatoid;
TNF-like weak inducer of apoptosis;
Survivin
- From:
Chinese Journal of Rheumatology
2010;14(11):759-761
- CountryChina
- Language:Chinese
-
Abstract:
Objective To measure the serum levels of TWEAK and survivin in rheumatoid arthritis (RA)patients and explore their clinical value. Methods The serum levels of TWEAK and survivin were measured by ELISA methods in 61 patients with RA and 35 healthy controls. The function stage, X-ray stage,and serum levels of ESR, RF and CRP were measured at the same time. Results There was no significant difference between the serum levels of TWEAK in patients with RA[(479±381)pg/ml]and control[(421±87 pg/ml]. The serum level of survivn in patients with RA[(159±82)pg/ml]was increased significantly than that of the controls[(119±24)pg/ml]and were associated with X-ray stage. Conclusion We need further research to explore the relationship between TWEAK and RA. The serum level of survivin is associated with chronic erosive RA and maybe a target for new therapeutic approach of RA.
