An update of nasal-type extranodal nature killer-T-cell lymphoma
10.3760/cma.j.issn.1673-422X.2010.11.021
- VernacularTitle:鼻型结外自然杀伤-T细胞淋巴瘤研究进展
- Author:
Liqiang WEI
- Publication Type:Journal Article
- Keywords:
Lymphoma,extranodal NK-T-cell;
Epstein-Barr virus infections;
Chromosome aberrations;
Gene expression;
Target therapy
- From:
Journal of International Oncology
2010;37(11):869-872
- CountryChina
- Language:Chinese
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Abstract:
Nasal-type extranodal nature killer-T-cell lymphoma (NKTCL) originates from mature nature killer (NK) cell or NK-like T cell. This lymphoma cells are usually CD3ε, CD56 and Epstein-Barr Virus (EBV) positive and the later plays an important role in the pathogenesis. A number of cell lines and animal models of NKTCL have been established and used in experimental studies. NKTCL always has various chromosome aberrations and the most common is 6q- which are not specific for the disease. Various abnormalities in genes expression and epigenetic also have been found, which might provide potential targets for target therapy in the future.
