Research progress in Caveolin-1s' role in gastrointestinal cancer

VernacularTitle:Caveolin-1在胃肠道肿瘤中的研究进展
Author: Yanlai SUN ; Yanan ZHEN
Publication Type:Journal Article
Keywords: Caveolin-1; Gastrointestinal neoplasms
From: Journal of International Oncology 2010;37(12):933-935
CountryChina
Language:Chinese
Abstract: Caveolin-1 is an important surface structural marker of Caveolae. It is closely involved in the proliferation, apoptosis, invasion, metastasis, angiogenesis, signal transduction and multi-drug resistance of various tumor cells. Recent studies have found that altered Caveolin-1 expression has dual roles, as a tumor suppressor and promoter, in different stages of gastrointestinal cancer development and progression. The exact mechanisms of Caveolin-1s' involvement in the development of gastrointestinal cancer remain to be clarified and have attracted the attention of a lot of researchers.