In vitro antimicrobial activity of piperacillin-sulbactam and other 7 antimicrobial agents against non-fermentative bacilli
10.3760/cma.j.issn.0578-1426.2010.12.007
- VernacularTitle:哌拉西林-舒巴坦等七种药物对非发酵菌体外抗菌活性的研究
- Author:
Chao ZHUO
;
Shunian XIAO
;
Guixia QIU
;
Nanshan ZHONG
- Publication Type:Journal Article
- Keywords:
Piperacillin-sulbactam;
Anti-bacterial agents;
Non-fermentative bacilli;
Microbial sensitivity tests
- From:
Chinese Journal of Internal Medicine
2010;49(12):1015-1019
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the in vitro antimicrobial activity of piperacillin-sulbactam against clinical isolates of non-fermentative bacilli isolated from common infections. Methods Microdilution was employed to study the antimicrobial resistance. Results A total of 770 strains were collected from 6 hospitals in Guangzhou, including Pseudomonas aeruginosa, Acinetobacter baumannii, Stenotrophomonas maltophilia , Burkholderia cepacia , Flavobacterium , and Alcaligenes. Compared with other β-lactams,piperacillin-sulbactam displayed the highest activity against all the isolates of P. aeruginosa, especially for imipenem non-sensitive isolates, with the susceptibility of 71.9% and 55.8%, respectively. Piperacillinsulbactam and cefoperazone-sulbactam kept good activity against imipenem sensitive isolates of A. baumannii,with the susceptibility of 71.0% and 73. 0%, respectively. For the strains of Burkholderia cepacia, 69% strains exhibited minimal inhibitory concentration (MIC) of ≤ 16 mg/L for piperacillin-sulbactam. For the strains of Flavobacterium, and Alcaligenes, piperacillin-sulbactam also had excellent activity, with the susceptibility of 70. 2% and 94. 4%, respectively. Conclusion Piperacillin-sulbactam exhibits good activity again non-fermentative bacilli, especial for imipenem non-sensitive isolates of P. aeruginosa.
