Changes of serum concentration of amino-terminal propeptide of procollagen type Ⅲ(P Ⅲ NP)of post-burn hypertrophic scar at excessive stages
10.3760/cma.j.issn.1673-4203.2010.11.003
- VernacularTitle:烧伤后增生性瘢痕患者不同时期血清中PⅢ NP的浓度变化及其意义
- Author:
Rui SHEN
;
Xiangsheng FENG
;
Hongmei SONG
;
Fenggang ZHANG
;
Xiaodong CHEN
;
Shubin RUAN
;
Zepeng LIN
;
Yan LIN
;
Jingqun ZHANG
- Publication Type:Journal Article
- Keywords:
Hypertrophic scar;
Post-burn;
Serum;
Marker;
PⅢNP
- From:
International Journal of Surgery
2010;37(11):726-728
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the level and the significance of amino-terminal propeptide of procollagen type Ⅲ(P Ⅲ NP)in the serum of hypertrophic scar patients at excessive stages.Methods The serum samples of 74 inpatients admmitted in Affiliated Fosham Hospital of Sun Yat-sen University from August 2007 to August 2009 suffering from long-persisting post-burn hypertrophic scar at various stages were collected.Serum samples of 12 were normal persons were also collected and used as control group.Hypertrophic scar group were divided into 4 subgroups according to the phase of scar and the serum concentrations of P Ⅲ NP were detected using the sensitive RIA method.Results The level of PⅢ NP increases gradually during the process of immature hypertrophic scar to mature scar before it peaking in 4 to 6 months scar subgroup.The concentration of PⅢ NP degreased gradually with the maturation of hypertrophic scar.Conclusions The high concentration of PⅢNP can reflect the high level of the synthesis of type Ⅲ collagen in the tissue of post-burn hypertrophic scar.The level of P Ⅲ NP is synonymous with the ongoing process of hypertrophic scar.PⅢ NP may be a satisfactory marker in discerning the growth and development of post-burn hypertrophic scar.
