Effect of short-term use of hypertonic saline on intracranial pressure, cerebral blood flow in poor-grade patients with subarachnoid hemorrhage while using hypertonic saline for short-term
10.3760/cma.j.issn.1673-4203.2010.11.009
- VernacularTitle:短期应用高渗盐水对重症蛛网膜下腔出血患者颅内压、脑血流量的影响
- Author:
Yunna YANG
;
Zheng GU
;
Tong LI
;
Xiangke MA
;
Haibo YANG
- Publication Type:Journal Article
- Keywords:
Subarachnoid hemorrhage;
Hypertonic saline;
Intracranial pressure;
Cerebral blood flow
- From:
International Journal of Surgery
2010;37(11):745-747
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of 23.4% hypertonic saline(HTS)on intracranial pressure(ICP), cerebral peffusion pressure(CPP), cerebral blood flow(CBF)in poor-grade patients with subarachnoid hemorrhage(SAH).Methods Sixteen patients(Glasgow coma score ≤ 8)with poor-grade SAH received 23.4% hypertonic saline intravenously for elevated ICP.ICP, mean arterial pressure(MAP), CPP and the middle cerebral artery flow velocity(FV)were observed and recorded before and at 30, 60, 90,120, 150, 180 min after the injection respectively.Results Thirty minutes postinfusion, a significant increase in MAP, CPP, FV was seen together with a decrease in ICP(P<0.05).ICP remained reduced for 180 minutes, CPP and FV remained elevated for 90 minutes(P < 0.05).Conclusions HTS can significantly decrease ICP and improve CBF in patients with poor-grade subarachnoid hemorrhage and may be used for reversal of pathophysiologic changes caused by cerebral ischemia.
