Relationship between GRIM-19 and cancers
10.3760/cma.j.issn.1673-4203.2010.11.014
- VernacularTitle:GRIM-19的生物学活性及其与肿瘤关系的研究进展
- Author:
Qizhu FENG
;
Chao ZHANG
- Publication Type:Journal Article
- Keywords:
GRIM-19;
Neoplasms;
Genes;
Apoptosis
- From:
International Journal of Surgery
2010;37(11):759-762
- CountryChina
- Language:Chinese
-
Abstract:
Gene associated with retinoid-IFN-induced mortality-19(GRIM-19)is originally isolated as a growth suppressive gene using a genetic screen.GRIM-19, initially found in nucleus and mitochondria, is essential for the assembly and functioning of mitochondrial complex I.GRIM-19 involves the regulation of cell proliferation and apoptosis, and low expression or mutation of GRIM-19 contributes to abnormal proliferation.During viral oncogenesis, GRIM-19 may be a general target protein similar to other cellular tumor suppressors.GRIM-19 plays an important role in tumor formation and apoptosis inhibition, and may be as a new tumor marker to early cancer screening.
