MicroRNA and cancer
10.3760/cma.j.issn.1673-422X.2010.12.001
- VernacularTitle:微RNA与肿瘤
- Author:
Xiaoting HE
- Publication Type:Journal Article
- Keywords:
MicroRNAs;
Neoplasms;
Neoplasm metastasis;
Therapy
- From:
Journal of International Oncology
2010;37(12):883-885
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs (MiRNAs) are a contemporary class of short non-coding RNAs,which play a critical role in diverse biological processes, including development, cell proliferation, differentiation, and apoptosis,by suppressing translation of protein coding genes, or cleaving target mRNAs of protein coding genes to induce their degradation. Accordingly, altered miRNA expression is likely to contribute to human disease, including cancer. This review will summarize the emerging knowledge of the association between human miRNA biology and different aspects of carcinogenesis, such as the development, metastesis and therapy strategies.
