Mechanism of nano drug delivery systems in overcoming P-gp mediated multi-drug resistance
10.3760/cma.j.issn.1673-422X.2010.12.008
- VernacularTitle:纳米载药系统逆转P-gp介导的肿瘤多药耐药的机制
- Author:
Lin CHENG
- Publication Type:Journal Article
- Keywords:
Nanotechnology;
P-Glycoprotein;
Drug resistance,multiple;
Neoplasms
- From:
Journal of International Oncology
2010;37(12):903-906
- CountryChina
- Language:Chinese
-
Abstract:
Multi-drug resistance (MDR) of cancer cells is a major cause of failure of chemotherapy in cancer treatment. Most MDRs are caused by overexpression of P-glycoprotein (P-gp) which effuses chemotherapeutic agents out of cells. Nano drug delivery systems (NDDS) have been valued for their characteristics including drug targeting, slow-releasing, and long circulation time in the body. Through mechanisms such as non-specific endocytosis and receptor-mediated endocytosis, NDDS can inhibit P-gp at the gene and protein level, leading to improved concentrations of chemotherapeutic drugs in cancer cells, and therefore reverse MDR.
