Experimental study on the therapeutic effect of aminoguanidine in rats with obstructive jaundice
10.3760/cma.j.issn.1673-4203.2010.11.004
- VernacularTitle:氨基胍对梗阻性黄疸大鼠治疗作用的实验研究
- Author:
Yaohua WU
;
Wenjie DAI
;
Hongchi JIANG
- Publication Type:Journal Article
- Keywords:
Aminoguanidine;
Obstructive jaundiceing
- From:
International Journal of Surgery
2010;37(11):729-731
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the therapeutic effect and mechanism of specific inducible nitric oxide synthase(iNOS)aminoguanidine(AG)in rats with obstructive jaundice.Methods Forty male Wistar rats were divided randomly into four groups: normal control group, sham operation group, obstructive jaundice group and aminoguanidine therapeutic group.Each group had 10 rats.We assayed levels of liver function,hemobilirubin, endotoxin,lactic acid and malondialdehyde before and after therapy, and we also analyzed pathology of the liver and small intestine.Then we could explore the therapeutic effect of AG in rats with obstructive jaundice.Results The levels of endotoxin,lactic acid and malondialdehyde in blood increased progressively along with the pathological changes of the liver and small intestine.Each of the AG group parameters was significantly lower, and the pathological changes of liver and small intestine were improved.Conclusion AG could protect liver and small intestine by attenuating lipid peroxidative and endotoxemia,and provide a new way to cure obstructive jaundice.
