Effects of valproic acid on leukemia
10.3760/cma.j.issn.1673-422X.2010.11.022
- VernacularTitle:丙戊酸对白血病作用的研究进展
- Author:
Kezhi HUANG
- Publication Type:Journal Article
- Keywords:
Histonc deacetylases;
Valproic acid;
Leukemia
- From:
Journal of International Oncology
2010;37(11):873-876
- CountryChina
- Language:Chinese
-
Abstract:
As a kind of histone deacetylase inhibitor (HDACJ), valproic acid (VPA) influences the development of leukemia by cell cycle arresting , apoptosis induction, fusion gene repression, homing interference and immune- regulation. The clinical combination of all-trans retinoic acid or DNA methyltransferase inhibitor with VPA has been demonstrated anti-leukemia effects. However, it needs further investigation on the anti-leukemia mechanism of VPA as well as its efficacy and safety in clinical application for leukemia patients.
