mTOR and its signaling pathway in gastric cancer
10.3760/cma.j.issn.1673-422X.2010.12.017
- VernacularTitle:哺乳动物雷帕霉素靶蛋白及其信号通路在胃癌中的研究进展
- Author:
Pengfei YU
- Publication Type:Journal Article
- Keywords:
Sirolimus;
Signal transduction;
Stomach neoplasms;
Antineoplastic protocols
- From:
Journal of International Oncology
2010;37(12):930-933
- CountryChina
- Language:Chinese
-
Abstract:
Mammalian target of rapamycin (mTOR) and its signaling pathway regulate protein synthesis, cell growth and metabolism, and angiogenesis. This pathway is highly activated in gastric cancer and closely related to the progression and prognosis of the cancer. Blocking the mTOR signaling pathway by rapamycin and its derivatives can inhibit gastric cancer cell growth and promote tumor necrosis and such effects can be synergistically improved by combined use of other chemotherapeutic agents. Thus, rapamycin and its derivatives may be effective in the prevention and treatment of gastric cancer.
