Association of EcoRI and XbaI polymorphisms of apolipoprotein B gene with dyslipidemia and lipid levels
10.3760/cma.j.issn.1008-1372.2010.11.005
- VernacularTitle:载脂蛋白B基因EcoRI和XbaI多态性与血脂异常及血脂水平的关系
- Author:
Yinjun XIE
;
Gang HUANG
;
Yehong CHI
- Publication Type:Journal Article
- Keywords:
Apolipoproteins B/GE;
Polymorphism,genetic;
Dyslipidemias/GE/ME;
Lipids
- From:
Journal of Chinese Physician
2010;12(11):1452-1456
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association of apoB gene polymorphisms with dyslipidemia and lipid levels in Xinjiang Shihezi Han Chinese. Methods 150 dyslipidemia patients and 150 normal pople were involved in this study. EcoRI and XbaI polymorphisms of apolipoprotein B was analyzed by PCR-restriction fragment length polymorphism. The levels of plasma total cholesterol, triglyceride, low density lipoprotein cholesterol, high density lipoprotein cholesterol, apoAI and apoB were determined. Results The frequency of E + E -/E - E - genotype and E-Allele(37.3% and 19% ) in dyslipidemia group was significantly higher than that in controls( 12. 7% and 6. 3% ). The levels of TC, TG and LDL-C in the E +E -/E - E - gene type were significantly higher than those of the E + E + gene type in each group ( P ＜0. 01 ). The frequency of X + X -/X + X + genotype and X + Allele( 20. 7% and 1 1% ) in dyslipidemia group was significantly higher than that in controls (8% and 4% ). The levels ofTC, TG, LDL-C and apoB in the X + X -/X + X + gene type patients were significantly higher than those in the X - X - gene type patients in every group ( P ＜ 0. 05 ). Conclusion The EcoRI and XbaI polymorphism of ApoB gene was related to dyslipidemia in population of Xinjiang Shihezi Han Chinese, and the E - and X + Allele may be the genetic risk factors for dyslipidemia.
