Effect of nutritional support combined with human growth hormone recombinant on nutritional status and immunological function in patients with mechanical ventilation
10.3760/cma.j.issn.1673-4904.2010.34.009
- VernacularTitle:营养支持联合重组人生长激素对机械通气患者营养状况及免疫功能的影响
- Author:
Zhijun ZHU
;
Jiexiong ZHANG
;
Sen ZHAO
- Publication Type:Journal Article
- Keywords:
Nutritional support;
Respiration,artificial;
Nutritional status
- From:
Chinese Journal of Postgraduates of Medicine
2010;33(34):23-26
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effects of nutritional support combined with human growth hormone recombinant (rhGH) in patients with mechanical ventilation. Methods One hundred and fifty cases in ICU were randomized into test group (nutritional support combined with rhGH, 80 cases) and control group (nutritional support,70 cases). Both groups received calories according to Harris-Benedict formula [N, 0.25 g/(kg· d)]. In addition, the test group received subcutaneous injections of rhGH at a dose of 0. 1 U/ (kg· d) for 7 days. The different effects on nutritional status indexes, immunological function indexes and clinical indexes were compared. Results Compared with the control group,there were significant improvement in nutritional status indexes and immunological function indexes after the treatment of 7 days. The success rate of once weaning was higher in test group than that in control group. There were significant differences in the level of transferrin, prealbumin, CD3, CD4, NK between two groups [(3.0 ± 0.6)g/L vs. ( 1.9 ± 0.4) g/L, (226.46 ± 27.02 ) mg/L vs. ( 188.68 ± 17.27 ) mg/L, (53.8 ± 3.3 ) % vs. (47.4 ±4.1 ) %, ( 0.41 ± 0.14 ) % vs. (0.25 ± 0.05 ) %, ( 16.1 ± 2.1 ) % vs. ( 10.9 ± 3.0 ) %] ( P ＜ 0.01 ). Conclusion rhGH combined with nutritional support has more effects on improving nutritional status compared with those of single nutritional support. It has significant adjustment effect on immunological function in patients with mechanical ventilation.
