Comparative study of clinic and pathologic data of hepatitis B virus ralated membranous nephropathy between children and adult
10.3760/cma.j.issn.1673-4904.2010.34.010
- VernacularTitle:儿童与成年人乙型肝炎病毒相关性膜性肾病的临床病理对比分析
- Author:
Xiaorong ZHONG
;
Yongze ZHUANG
;
Ting LIN
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus;
Nephrotic syndrome;
Membranous nephropathy
- From:
Chinese Journal of Postgraduates of Medicine
2010;33(34):27-29
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the similarities and differences of clinical manifestation and pathological characteristics in hepatitis B virus related membranous nephropathy (HBV-MN) between children and adult. Methods Ninety cases with HBV-MN were divided into two groups according to the age:children group (33 cases) and adult group (57 cases). A retrospective control study was carried out to analyze the clinical and pathological features of the two groups. Results The incidence of anemia in children group was 45.45% ( 15/33 ), which was significantly higher than that in adult group [15.79% (9/57)](P ＜ 0.01). Nephrotic syndrome was the largest proportion in two groups,but there was no significant difference in the composition of clinical manifestations between two groups (P ＞0.05). Membranous nephropathy Ⅱ was common in pathological stage in two groups. The incidence of membranous nephropathy Ⅱ in children group was 63.64% (21/33),which was significantly higher than that in adult group [42.11%(24/57)] (P ＜ 0.05 );immunohistochemistry showed "all bright", and the deposition of HBcAg in renal biopsy was also higher than that in adult group (P ＜ 0.05). Conclusion There are some similarities and differences in HBV-MN between children and adult patients,and these will help to improve the levels of diagnosis and treatment.
