Clinical study of influence of low molecular weight heparin on coagulation function in elderly patients after thoracic surgery
10.3760/cma.j.issn.1673-4904.2010.32.001
- VernacularTitle:低分子量肝素对胸外科高龄患者术后凝血功能影响的临床研究
- Author:
Ni ZHANG
;
Xiangning FU
;
Qinzi XU
- Publication Type:Journal Article
- Keywords:
Thoracic surgical procedures;
Diabetes mellitus;
Blood coagulation disorders;
Heparin,low-molecularweight;
Aged
- From:
Chinese Journal of Postgraduates of Medicine
2010;33(32):1-4
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the changes of blood coagulation system and the clinical interventional effect of low molecular weight heparin (LMWH) in elderly patients who had received thoracic surgery. Methods Ninety-six thoracic surgery patients (age≥70 years) were divided into control group ( 54 cases ) and experimental group ( 42 cases ) ( postoperative 1-7 days, subcutaneous injection with LMWH ) from September 2007 to December 2009 by random digits table. Observed perioperative changes in prothrombin time (PT),activated partial thromboplastin time (APTT),platelet (Plt),D-dimer (D-D),fibrinogen (Fib), anti- X a activity, and clinical performances. Also observed the influence of diabetes mellitus of surgery coagulation function. Results The preoperative indexes of coagulation function were no significant (P ＞ 0.05 ). In control group PT prolonged, Fib and D-D increased, the differences between preoperative and postoperative each time were significant (P ＜ 0.05 ). Fib and D-D in control group increased than those in experimental group postoperative each time (P ＜ 0.05 ). In experimental group anti- X a activity increased postoperative each time (P ＜ 0.05 ),compared with control group was also significant (P ＜ 0.05 ). Diabetes mellitus had no significant influence on coagulation function. One patient appeared pulmonary thromboembolism in control group,and no one appeared venous thromboembelism and bleeding adverse reactions in experimental group. Conclusion Thoracic surgery in elderly patients have high blood coagulation state, prone to venous thromboembolism, LMWH given early postoperative prophylactic treatment is beneficial to improve the hypercoagulable state and have better security.
