The correlation of GULP1 gene polymorphism with the cognitive function in schizophrenia

VernacularTitle:GULP1基因多态性与精神分裂症及其认知功能的相关性研究
Author: Jun LIU ; Hong YU ; Baoluo GU ; Chaoqi HE
Publication Type:Journal Article
Keywords: Schizophrenia; Polymorphism,single nucleotide; Cognition
From: Chinese Journal of Primary Medicine and Pharmacy 2010;17(21):2926-2928
CountryChina
Language:Chinese
Abstract: Objective To discuss the relationship between GULP1 gene polymorphism of Chinese Han population and schizophrenia,cognitive function.Methods Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) method was used to detect 86 patients with schizophrenia and 72 normal controls GULP1 gene SNPrs2004888 polymorphism;Wechsler Memory Scale(WMS) and Wisconsin Card Sorting Test(WCST) assessment of two groups of memory and executive function,and assessed with the PANSS scale clinical symptoms.Results The differences of GULP1 gene SNP(rs2004888) polymorphism genotype and allele frequency was statistically significant (χ2 = 35.71、32.21,all P＜0.05).Genotypes in patients with group comparison of cognitive function between groups showed the genotype groups Wechsler Memory Scale Logical Memory scores were significant(P＜0.05),G/G and T/T genotype compared with the Wisconsin Card Sorting Test in the number of errors,error numbers and classification numbers significant(P＜0.05).Conclusion GULP1 gene SNPrs2004888 polymorphism was associated with schizophrenia,and also related to cognitive function in schizophrenia.