Clinical significance of autoimmune antibody in patients with lupus nephritis

VernacularTitle:狼疮肾炎患者血清自身抗体检测及意义
Author: Li WANG ; Lin WANG
Publication Type:Journal Article
Keywords: Lupus nephritis; Complement C1q; Antibodies,antinuclear
From: Chinese Journal of Primary Medicine and Pharmacy 2010;17(21):2917-2918
CountryChina
Language:Chinese
Abstract: Objective To investigate the clinical significance autoimmune antibody in patients with lupus nephritis(LN).Methods ELISA assay was performed to examine anti-C1q antibody and anti-nucleus antibody;immunoblot assay was performed to examine anti-dsDNA antibody,anti-nucleosome antibody and anti-Sm antibody in sera of 38 patients with LN and 22 patients of system lupus erythemalosus without renal damage.Standard methods were uaed for laboratory testing.Results The positive rate of anti-C1q antibody,anti-dsDNA antibody,anti-nucleosome antibody,anti-Sm antibody and anti-nucleus antibody were significantly higher in LN than in controls(P＜0.01).AntiC1q antibody and anti-nucleus antibody were significantty higher in LN than in controls(P＜0.01,P＜0.05).Serum levels of anti-C1q antibody was positively correlated with SLEDAI score and the level of anti-nucleus antibody,but was negatively oorrelated with C3、 C4.Conclusion Anti-C1q antibody,anti-dsDNA antibody,anti-nucleosome antibody and anti-nucleus antibody are suggested to play a role in the pathogenesis of LN and can be used as diagnostic tools and disease activity markers.