MicroRNA-126 and tumor
10.3760/cma.j.issn.1673-422X.2010.12.002
- VernacularTitle:微RNA-126与肿瘤
- Author:
Yongchao LIU
;
Jie FAN
- Publication Type:Journal Article
- Keywords:
MicroRNAs;
Neoplasms;
Lung neoplasms;
Leukemia;
Breast neoplasms
- From:
Journal of International Oncology
2010;37(12):885-888
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNAs can post-transcriptionally regulate the expression of their target mRNAs. MicroRNA-126 plays an important role in tumorigeness by targeting EGFL7, HOXA9, IRS-1 and p85-β. Intriguingly, it is downregulated in a wide range of tumors and is testified that it functions as a tumor suppressor in lung cancer, leukemia, breast cancer and ovarian cancer.
