Detection of Y Chromosome Microdeletion is Valuable in the Treatment of Patients With Nonobstructive Azoospermia and Oligoasthenoteratozoospermia: Sperm Retrieval Rate and Birth Rate.
10.4111/kju.2013.54.2.111
- Author:
Don Kyung CHOI
1
;
In Hyuck GONG
;
Jin Ho HWANG
;
Jong Jin OH
;
Jae Yup HONG
Author Information
1. Department of Urology, CHA Bundang Medical Center, CHA University, Seongnam, Korea. honguro4@hanmail.net
- Publication Type:Original Article
- Keywords:
Assisted reproductive techniques;
Azoospermia;
Male infertility;
Sperm retrieval;
Y chromosome
- MeSH:
Avena;
Azoospermia;
Birth Rate;
Chromosome Deletion;
Chromosomes, Human, Y;
Fertilization;
Humans;
Infertility, Male;
Male;
Parturition;
Prognosis;
Reproductive Techniques, Assisted;
Retrospective Studies;
Sex Chromosome Aberrations;
Sex Chromosome Disorders of Sex Development;
Sperm Retrieval;
Spermatozoa;
Y Chromosome
- From:Korean Journal of Urology
2013;54(2):111-116
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: We evaluated clinical characteristics, sperm retrieval rates, and birth rates in a relatively large number of infertile patients with Y chromosome microdeletions. MATERIALS AND METHODS: We retrospectively reviewed clinical data from 213 patients with nonobstructive azoospermia (NOA) and 76 patients with oligoasthenoteratozoospermia (OATS) who were tested for Y chromosome microdeletion from March 2004 to June 2011. RESULTS: Of the 289 patients, 110 patients presented with Y chromosome microdeletion and 179 patients presented with no microdeletion. Among the patients with Y chromosome microdeletions, 83/110 (75.4%) were NOA patients and 27/110 (24.5%) were OATS patients. After subdividing the patients with Y chromosome microdeletion, 29 had azoospermia factor (AZF)b-c microdeletion and 81 had AZFc microdeletion. The sperm retrieval rate was similar between patients with Y chromosome microdeletion and those with no microdeletion (26.6% vs. 25.6%, p=0.298) after multiple testicular sperm extraction (TESE). Excluding 53 patients who did not undergo TESE, 30 patients were analyzed. All of the 9 men with AZFb-c microdeletion had a complete absence of sperm despite multiple TESE. However, multiple TESE was successful for 9 of 21 patients with only AZFc microdeletion (p=0.041). Twenty patients with Y chromosome microdeletion gave birth. CONCLUSIONS: In NOA and OATS patients, no significant difference in the sperm retrieval rate was shown between patients with Y chromosome microdeletion and those with no microdeletion. Patients with short Y chromosome microdeletion such as AZFc microdeletion have better prognoses for sperm retrieval and an increased chance of conception than do patients with larger microdeletions such as AZFb-c microdeletion.
