Phase Ⅱ metabolic enzyme gene polymorphism and risk of cancer
10.3760/cma.j.issn.1673-422X.2010.11.002
- VernacularTitle:Ⅱ相代谢酶基因多态性与肿瘤易感性
- Author:
Jian JI
;
Nan LI
- Publication Type:Journal Article
- Keywords:
Polymorphism;
Gene;
Neoplasms;
Phase Ⅱ metabolic enzyme
- From:
Journal of International Oncology
2010;37(11):806-809
- CountryChina
- Language:Chinese
-
Abstract:
Phase Ⅱ metabolic enzymes play pivotal role in the biotransform and metabolism of exogenous substances, which might influence its ability of metabolism and detoxification to exogenous carcinogens.Polymorphism have been demonstrated in various phase Ⅱ metabolic enzymes and etiology studies showed that individuals exposed to the same environment could develop different susceptibility to tumorigenesis due to different metabolic enzyme polymorphism. Here, we summarized the effects of phase Ⅱ metabolic enzyme polymorphism on the risk of cancer.
