Non-small cell lung cancer: evaluation of the relationship between fibrosis and washout feature at dynamic contrast enhanced CT
10.3760/cma.j.issn.1005-1201.2010.12.015
- VernacularTitle:周围型非小细胞肺癌间质内纤维化与CT动态增强廓清参数相关性研究
- Author:
Xiaodan YE
;
Zheng YUAN
;
Jianding YE
;
Huimin LI
;
Yuzhao ZHU
;
Shunmin ZHANG
;
Shiyuan LIU
;
Xiangsheng XIAO
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
Tomography,X-ray computed;
Pulmonary fibrosis
- From:
Chinese Journal of Radiology
2010;44(12):1290-1293
- CountryChina
- Language:Chinese
-
Abstract:
Objective To correlate dynamic parameters at contrast enhanced CT and interstitial fibrosis grade of non-small cell lung cancer (NSCLC). Methods Twenty-nine patients with NSCLC were evaluated by multi-slice CT. Images were obtained before and at 20,30,45,60,75,90,120,180,300,540,720,900 and 1200 s after the injection of contrast media, which was administered at a rate of 4 ml/s for a total of 420 mg I/kg body weight. Washout parameters were calculated. Lung cancer specimens were stained with hematoxylin-eosin stain and collagen and elastica double stain. Spearman test was made to analyze correlation between dynamic parameters and interstitial fibrosis grade of tumor. Results Twentynine NSCLC demonstrated washout at 20 min 12. 1 (0. 32-58.0 ) HU, washout ratio at 20 minutes 15.3% (0. 3%-39.2% ), slope of washout at 20 minutes 0. 0152 %/s ( 0. 0007%/s-0. 0561%/s ).Interstitial fibrosis of 29 lesions was graded as grade Ⅰ (10), grade Ⅱ (14) and grade Ⅲ (5). There were significant correlation between washout at 20 min ( r = - 0. 402, P ＜ 0. 05 ), washout ratio at 20 min ( r =-0.372,P＜0.05), slope of washout ratio (r = -0.459,P ＜0.05) and interstitial fibrosis grade in tumors. Conclusion NSCLC washout features at dynamic multi-detector CT correlates with interstitial fibrosis in the tumor.
