Changes of CD19 + CD5 + B cells and BAFF in endometriosis

VernacularTitle:子宫内膜异位症患者中CD19+CD5+B细胞及BAFF变化的研究
Author: Yanping JIANG ; Ruoyu LUO ; Lang CHEN
Publication Type:Journal Article
Keywords: Endometriosis/ME/IM; B-lymphocytes/ME; Antigens,CD19/ME; Antigens,CD5/ME; B-cell activating factor/ME
From: Journal of Chinese Physician 2010;12(11):1467-1470
CountryChina
Language:Chinese
Abstract: Objective To explore the changes of frequency, BAFF expression and sensitivity to apoptosis of CD19 + CD5 + B cells in endometriosis patients and investigate the relationship between CD19 +CD5 + B cells and endometriosis. Methods Flow cytometry and quantitative PCR were used to assess the frequency, BAFF expression and sensitivity to apoptosis of CD19+ CD5 + B cells in the peripheral blood,peritoneal fluids and endometrium biopsies of 39 patients with endometriosis and 31 patients with myoma of uterus ( control subjects). Results: All 39 endometriosis patients had higher frequencies ( all P ＜ 0. 01 ) of CD19 + CD5 + B cells in the peripheral blood, peritoneal fluids and endometrium biopsies than that in 31 control subjects. CD19 + CD5 + B cells from endometriosis patients expressed higher BAFF, and were more resistant to CD95L-induced apoptosis than the cells from control subjects ( P ＜ 0. 01 ). Conclusion CD19 + CD5 + B cells might play an important role in the pathogenesis of endometriosis through higher BAFF expression and more resistance to CD95L-induced apoptosis.