Neutrophil gelatinase- associated lipocalin for diagnosis of acute kidney injury after cardiopulmonary bypass

VernacularTitle:尿NGAL在体外循环术后急性肾损伤早期诊断中的意义
Author: Jingsheng ZHAO ; Tiejun WU ; Weiguo YI ; Zheng LI ; Fumin TANG ; Jian XIONG ; Yuncheng LUO
Publication Type:Journal Article
Keywords: Lipocalins/ME; Extracorporeal circulation/AE; Kidney diseases/ET/DI; Kidney/IN
From: Journal of Chinese Physician 2010;12(11):1471-1473
CountryChina
Language:Chinese
Abstract: Objective To evaluate the value of neutrophil gelatinase - associated lipocalin (NGAL) for diagnosis of acute kidney injury (AKI) after cardiopulmonary bypass established. Method 120 children undergoing cardiopulmonary bypass were enrolled in this prospectively study. Serial urine samples were analyzed by ELISA for NGAL expression. The primary outcome measure was AKI, which was defined as a 50% or greater increase in serum creatinine from baseline. Result 21 children ( 17.5% ) developed AKI. Urine concentrations of NGAL increased after cardiopulmonary bypass had been established for 2 hours. The concentration of NGAL in urine after cardiopulmonary bypass had been established for 2 hours was used to diagnose AKI. The area under the receiver-operating characteristic curve was 0. 96, the sensitivity was 92%, and the specificity was 91% for the cutoff value of 100ng/mg Cr. Conclusion Concentrations of NGAL in urine might be used as a sensitive and specific biomarker for early prediction of AKI after cardiopulmonary bypass had been established.