Metabolic characteristics and usage of tacrolimus in patients subject to living-donor partial liver transplantation
10.3760/cma.j.issn.0254-1785.2010.12.010
- VernacularTitle:活体部分供肝移植术后他克莫司的用量及代谢特点
- Author:
Xiaoyin TANG
;
Qiang XIA
;
Jianjun ZHANG
;
Qigen LI
;
Ning XU
;
Xiaosong CHEN
;
Xin WANG
;
Longzhi HAN
;
Yi LUO
;
Tianyu XING
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
Living donors;
Tacrolimus
- From:
Chinese Journal of Organ Transplantation
2010;31(12):749-752
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the metabolic characteristics, dosages and blood concentrations of tacrolimus (Tac) in patients subject to cadaveric liver transplantation (CLT) vs living-donor partial liver transplantation (LDLT) in order to investigate the usage of Tac in patients undergoing LDLT. Methods The clinical data of 85 patients undergoing liver transplantation from April 2007 to September 2009 were analyzed retrospectively. Thirty-four underwent LDLT (group A)and the remaining 51 underwent CLT (group B). Results The time to reach therapeutic window was shorter in group A (3. 4 ± 1.0 days) than in group B (4. 5 ± 2. 0 days, P = 0. 002). The Tac dosage in group A was significantly less than in group B during the first 28 days post-transplantation. However,the Tac dosage approached gradually and tended to be consistent after 28 days. On the postoperative day7, 14, 21 and 28 days, the Tac dosage in group A was 72.74 ％, 82.26 ％, 83.92 ％ and 88. 87 ％ of that in group B respectively. Correlation analysis revealed that graft-recipient body weight ratio (GR/WR) was significantly correlated with the Tac dosage on the day 7 (mg·day-1 · kg-1) (r =0. 728, P＜0. 01) and Tac concentration/dosage ratio (ng/ml)/(mg/kg) (r = - 0. 644, P＜0. 01 ).Conclusion The early Tac dosages in patients subject to LDLT were correlated significantly with the volume of graft. The early Tac dosages in patients undergoing LDLT were about 70 ％ of those in patients undergoing cadaveric liver transplantation. Moreover, with the regeneration of the liver, they tended to be consistent after 28 days.
