Expression of p73 and its correlation with Survivin in colon carcinoma

VernacularTitle:结肠癌中P73和Survivin的表达及临床意义
Author: Di LU ; Yunhui FU
Publication Type:Journal Article
Keywords: Colonic neoplasms/ME; Microtubule-associated proteins/ME; DNA-binding proteins/ME; Nuclear proteins/ME
From: Journal of Chinese Physician 2010;12(11):1482-1484
CountryChina
Language:Chinese
Abstract: Objective To study the expression of P73 and its relationship with expression of Survivin in colon carcinoma. Methods The expression of P73 and Survivin was studied by immunohistochemical technique in 46 cases of colon carcinoma and 12 cases of normal colon mucosa. Results The P73 expression rate of colon carcinoma was significant higher than that of normal colon mucosa(χ2 = 13.42, P ＜0.01 ). Overexpression of P73 was related to the pathological grade and Dukes stage ( ( χ2 = 8.01, P ＜0.01 ), and it was closely related to lymphatic metastasis of colon carcinoma( P ＜0.01 ). There was a positive relation between P73 and Survivin( rs =0.487, P ＜0.01 ). Conclusions The expression of P73 was closely associated with Survivin in colon carcinoma. The results suggested that the overexpression of P73 and Survivin was involved in the tumorigenesis and development of colon carcinoma and P73 and Survivin might be used as a new tumor marker in metastasis and prognosis of colon carcinoma.