Relationships among the expression of VEGF, MMP-2 , MMP-9 and metastasis in breast carcinoma
10.3760/cma.j.issn.1008-1372.2010.11.017
- VernacularTitle:MMP-2、MMP-9和VEGF与乳腺癌侵袭转移关系的研究
- Author:
Junwei ZHANG
;
Yi ZHANG
;
Changzheng MU
- Publication Type:Journal Article
- Keywords:
Matrix metalloproteinase 2/ME;
Matrix metalloproteinase 9/ME;
Vascular endothelial growth factors/ME;
Breast neoplasms/ME/PA;
Neoplasm invasiveness;
Neoplasm metastasis
- From:
Journal of Chinese Physician
2010;12(11):1490-1493
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of VEGF, MMP-2 and MMP-9 in benign and malignant lesions of breast and their effects on breast carcinoma's invasiveness and metastasis. Methods VEGF,MMP-2 and MMP-9 expression was detected by SP method in 20 breast fibroadenoma and 12 normal breast specimens taken from non-cancerous regions adjacent to breast cancer tissue and 38 breast carcinomas. Results The expression rate of VEGF, MMP-2 and MMP-9 in breast carcinoma was remarkably higher than those in normal breast tissue and breast fibrogdenoma (63.2% vs 25.0% and 30. 0% ,78. 95% vs 33.3% and 35.0% and 71.1% vs 41.7% and 45.0% ,respectively; P ＜0.05). There was a correlation between VEGF, MMP-2 and MMP-9 expression and nodal metastasis ( P ＜0.05). High expression of VEGF, MMP-2 and MMP-9 was correlated with pathological grade ( P ＜ 0.05, respectively). The overexpression of VEGF was related with those of MMP-2 and MMP-9 in breast cancer( VEGF and MMP-2:rs =0.541, P ＜0.01 ;VEGF and M M P-9: rs = 0.11, P ＜ 0.01; MMP-2and M MP-9: rs= 0P ＜ 0.01 ). Conclusion VEGF,MMP-2 and MMP-9 overexpression is strongly related to the invasiveness and metastasis of breast carcinoma, which might be valuable in evaluating tumor invasion and metastasis.
