Prevalence and risk factors for aspirin resistance in elderly patients with type 2 diabetes
10.3760/cma.j.issn.0254-9026.2010.11.002
- VernacularTitle:老年2型糖尿病患者阿司匹林抵抗的发生率及相关危险因素分析
- Author:
Lin LIU
;
Jian CAO
;
Li FAN
;
Weijun HAO
;
Guoliang HU
;
Yixin HU
;
Xiaoli LI
;
Shasha ZHAO
;
Ke MIAO
;
Rongqiang ZHANG
;
Lan XUE
;
Haiyan SHI
;
Bingpo ZHU
;
Hao WANG
;
Jian LI
;
Jie BAI
;
Yulong CONG
- Publication Type:Journal Article
- Keywords:
Aspirin;
Bleeding time;
Diabetes mellitus,type 2;
Risk factors
- From:
Chinese Journal of Geriatrics
2010;29(12):973-976
- CountryChina
- Language:Chinese
-
Abstract:
Objective Although aspirin resistance has been recognized to occur in patients with diabetes mellitus, the prevalence and related risk factors for aspirin resistance in elderly patients with diabetes mellitus have not been reported yet. The purpose of the present study was to evaluate the prevalence and potential risk factors for aspirin resistance in elderly patients with type 2 diabetes.Methods The 140 elderly patients [aged from 60 to 92 years, mean age (73.8±8. 0) years] with type 2 diabetes receiving daily aspirin therapy (≥ 75 mg) over one month were recruited. Platelet aggregation was measured by light transmittance aggregometry (LTA) and thrombelastograph (TEG)platelet mapping assay. Results By LTA, 6 patients (4.3%) of the diabetic patients were found to be resistant to aspirin therapy, 44 patients (31.4 %) were semi-responders. By TEG, 31 patients (22. 1%) were aspirin resistant. Among the 31 patients who were aspirin resistant by TEG, 3 were aspirin resistant by LTA. In the multivariate logistic regression analysis, female gender (OR= 5. 54,95%CI: 1.17-27.47, P=0.036) and homocysteine level (OR=1.15, 95%CI: 1.00-1.35, P=0. 043) were statistically significant risk factors for aspirin resistance by TEG. Conclusions The prevalence of aspirin resistance in elderly patients with type 2 diabetes is considerably higher in elderly female patients and in elderly patients with higher serum homocysteine level.
