Clinical study in effect of edaravone on free radical scavenging in patients with acute cerebral infarction

VernacularTitle:依达拉奉对急性脑梗死患者自由基清除的临床研究
Author: Qiuhua ZHOU ; Chunxiao WAN ; Xiaojie LU
Publication Type:Journal Article
Keywords: Cerebrovascular accident; Free radical scavengers
From: Chinese Journal of Geriatrics 2010;29(12):987-988
CountryChina
Language:Chinese
Abstract: Objective To investigate the clinical effect of edaravone on free radical damage after acute stroke. Methods The 60 patients with acute stroke were randomly divided into therapy group and control group. Both the groups were treated with routine approaches of dehydration, intracranial pressure reducing and blood pressure control. The treatment with balanced saline 250 ml plus edaravone 30 mg, intravenously infusion twice a day, was adopted in therapy group, while the control group received balanced saline 250 ml only, the treatment lasted for 14 days. Before and 14 days after treatment, the neurologic impairment analysis, activity of daily living scale (ADL) and serum superoxide dismutase (SOD) were checked. Results Compared with control group, after 14 dtreatment, the improvements in neurologic impairment analysis (7.5±5.4 vs. 15.9±7.9, P＜0.05),ADL (58.32±11.57 vs. 43.73± 12.48, P＜0.05) and SOD[(157.25±21.81)mmol/L vs. (127.08 ± 13. 14)mmol/L, P＜0. 05] occurred in therapy group. Conclusions Edaravone could increase the ability of cleaning free radicals and promoting function of nerves recovery.