Significance of cortactin expression in primary liver cancer

VernacularTitle:皮层肌动蛋白在原发性肝癌中表达的意义
Author: Gang ZHAO ; Hongyi ZHANG ; Li REN ; Yalin KONG ; Yu LI
Publication Type:Journal Article
Keywords: Liver neoplasms; Cortactin; Immunohistochemistry
From: Chinese Journal of Digestive Surgery 2010;09(6):444-446
CountryChina
Language:Chinese
Abstract: Objective To investigate the significance of cortactin in primary liver cancer. Methods Fiftythree paraffin embedded primary liver cancer specimens were collected at General Hospital of Air Force of PLA from January 2002 to May 2008. The expression of cortactin was detected by immunohistochemistry, and the relationship between cortactin expression and clinicopathologic parameters was analyzed. All data were analyzed via Wilcoxon rank sum test and Spearman rank correlation analysis. Results There was a significant difference in cortactin expression among tumor capsule integrity, TNM staging, portal vein tumor thrombus and extrahepatic metastasis (u =2. 19, 3. 584, 2. 796, P ＜ 0.05 ). There was a positive correlation between tumor invasion and cortactin expression ( r = 0. 5794, P ＜ 0.05 ). Conclusions Overexpression of cortactin may be one of the factors enhancing the invasion of primary liver cancer. The level of cortactin expression can be used in evaluating the invasive potential of primary liver cancer.