Clinical study of N-terminal prohormone brain natriuretic peptide and tissue Doppler imaging in left ventricular diastolic dysfunction
10.3760/cma.j.issn.1673-4904.2010.34.007
- VernacularTitle:血浆氨基末端B型钠尿肽前体及组织多普勒成像评价左室舒张功能不全价值的研究
- Author:
Chuangao YANG
;
Zhiming YU
;
Huayan YOU
;
Di ZHANG
;
Xiaoqing WU
- Publication Type:Journal Article
- Keywords:
Natriuretic peptide,brain;
Ultrasonography,Dopple;
Ventricular dysfunction,left
- From:
Chinese Journal of Postgraduates of Medicine
2010;33(34):18-19
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the value of N-terminal prohormone brain natriuretic peptide (NT-proBNP) and tissue Doppler imaging (TDI) in patients with left ventricular diastolic dysfunction.Methods Forty-three patients with diastolic heart failure were enrolled. Pulsed wave (PW) Doppler technology was used to detect early diastolic mitral velocity (E) and TDI was performed to determine the mitral annulus velocity of early diastolic phase (Em). According to the E/Em, patients were divided into three groups: group Ⅰ (E/Em ＜8),group Ⅱ (E/Em 8-15) and group Ⅲ (E/Em ＞ 15). The plasma NT-proBNP was measured. Results The plasma NT-proBNP in group Ⅲ [( 1119 ± 3123) ng/L] was higher than that in group Ⅱ [(684± 1742) ng/L] and group Ⅰ [(276±438) ng/L] (P＜0.01),and the plasma NT-proBNP in group Ⅱ was higher than that in group Ⅰ (P ＜ 0.01 ). The plasma NT-proBNP had positive correlation with E/Em (r = 0.438,P ＜ 0.01 ). Conclusion The plasma NT-proBNP and TDI are useful to evaluate the left ventricular diastolic dysfunction.
