A retrospective study on rapid eye movement sleep behavior disorder in Parkinson's disease
10.3760/cma.j.issn.1006-7876.2010.12.011
- VernacularTitle:帕金森病患者快速眼球运动睡眠行为障碍的回顾分析及前瞻性研究
- Author:
Mingzhu ZHOU
;
Zhenguo LIU
;
Jiaying WU
;
Lixia LU
;
Jing GAN
;
Haiyan HE
;
Wei CHEN
- Publication Type:Journal Article
- Keywords:
Parkinson disease;
REM sleep behavior disorder;
Retrospective studies;
Prospective studies
- From:
Chinese Journal of Neurology
2010;43(12):858-862
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the prevalence of rapid eye movement(REM)sleep behavior disorder(RBD)in patients with Parkinson' s disease(PD)and to investigate the risk factors of PD-RBD and its effect on the progress of PD. Methods Using the minimal diagnostic criteria of parasomnias described in the International Classification of Sleep Disorders-Revised(ICSD-R)to diagnose clinically probable RBD(cpRBD), patients were assessed by Unified Parkinson's Disease Rating Scale(UPDRS),MMSE, Montreal Cognitive Assessment(MoCA)at baseline and followed for 2.5 years. Results The frequency of cpRBD ranged from 35.6%(47/132)to 41.7%(55/132)during the study period. 11.4% (15/132)patients dropped out from the study. Lower MoCA score and type of onset are independent factors with cpRBD; Lower MoCA score(OR =0. 817 ,P =0. 004)is the risk factor while tremor(OR =0. 247 ,P =0. 020)is the protective factor. PD in patients with PD-RBD may progress more rapidly than non PD-RBD patients(UPDRS Ⅲ change from baseline 9. 86 ± 4. 96 vs 6. 76 ± 4. 26, t = 2. 909, P = 0. 005; H-Y change from baseline 0. 77 ± 0. 54 vs 0. 33 ± 0. 49, t = 3. 664, P = 0. 000). Conclusion RBD may be a symptom predictive for rapid PD progression, declining cognition and psychosis.
