The Expression of Cyclooxygenase-2 and Survivin in Urinary Bladder Transitional Cell Carcinoma.
- Author:
Tae Jung JANG
1
;
Kyung Seob LEE
Author Information
1. Department of Pathology, Dongguk University College of Medicine, Gyeongju, Korea.
- Publication Type:Original Article
- Keywords:
Bladder cancer;
Cyclooxygenase-2;
Survivin
- MeSH:
Carcinoma, Transitional Cell;
Cyclooxygenase 2;
Cytoplasm;
Immunohistochemistry;
Mucous Membrane;
Recurrence;
Urinary Bladder;
Urinary Bladder Neoplasms
- From:Korean Journal of Pathology
2009;43(3):206-211
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The aim of this study was to investigate the expressions of cyclooxygenase-2 (COX-2) and survivin in bladder transitional cell carcinoma (TCC) that has different clinicopathologic characteristics, and we also wanted to determine if a relation exists between the COX-2 and survivin expressions. METHODS: The expressions of COX-2 and survivin were investigated in 80 bladder TCCs by performing immunohistochemistry. RESULTS: The normal bladder mucosa did not express COX-2 and survivin. COX-2 immunopositivity and cytoplasmic survivin immunopositivity were seen in 48% and 30% of bladder tumors, respectively. The expressions of COX-2 and survivin were closely related to the differentiation, depth and recurrence of bladder TCC, and there was a significant correlation in topographic distribution of COX-2 and survivin immunopositivity. In addition, COX-2 and survivin were predominantly expressed at the invasive front of tumors. CONCLUSIONS: This data suggest that COX-2 and survivin may be involved in the progression of bladder TCC, and there is a close correlation between the expressions of COX-2 and survivin.
