Application of exogenous creatine phosphate for cardiac valve replacement
10.3760/cma.j.issn.1673-4904.2010.27.001
- VernacularTitle:外源性磷酸肌酸在心脏瓣膜置换术中的应用
- Author:
Fanhao MENG
- Publication Type:Journal Article
- Keywords:
Phosphocreatine;
Extracorporeal circulation;
Myocardium;
Valve replacement
- From:
Chinese Journal of Postgraduates of Medicine
2010;33(27):1-3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the myocardial protection of exogenous creatine phosphate (CP) for cardiac valve replacement patients with cardiopulmonary bypass (CPB). Methods Forty patients undergoing cardiac valve replacement with CPB were randomly divided into CP group (20 cases) and control group (20 cases). In CP group,CP (10 mmol/L) was added into blood cardioplegia solution, and before aortic unclamping, perfused with warm blood plus CP (10 mmol/L) for 5 minutes. In control group without CP. The effect of myocardial protection of the two methods were evaluated. Results The ratio of myocardial auto-resuscitation was higher in CP group than that in control group [90.0%(18/20) vs. 60.0%(12/20)]( P ＜ 0.05 ). The maximal dose of dopamine was lower in CP group than that in control group [ (4.0 ± 0.9) g/(kg·min) vs. (6.5 ± 1.2) g/ (kg·min)](P＜ 0.05). The levels of serum creatine kinase MB (CK-MB) at 4,10 hours after aortic unclamping were lower in CP group than those in control group[ (32.4 ± 5.2) U/L vs.(43.8 ± 5.8) U/L and (23.7 ± 5.3 ) U/L vs. (33.5 ± 6.0) U/L ] (P ＜ 0.05 ). Conclusion Exogenous CP shows positive myocardial protection in the patients undergoing cardiac valve replacement.
