Effect of rosiglitazone on glucose tolerance in newly-diagnosed type 2 diabetes patients

VernacularTitle:罗格列酮对初发2型糖尿病患者糖耐量的影响及相关因素
Author: Baocheng CHANG ; Tong WANG ; Chunyan SHAN ; Miaoyan ZHENG ; Yun XIE ; Lirong SUN ; Lihua ZHANG ; Liming CHEN ; Ping FENG
Publication Type:Journal Article
Keywords: Rosiglitazone; Diabetes; Glucose tolerance; Restoration
From: Chinese Journal of Endocrinology and Metabolism 2010;26(12):1035-1037
CountryChina
Language:Chinese
Abstract: One hundred and thirteen newly-diagnosed type 2 diabetic patients were treated with rosiglitazone for 16 weeks. Glucose tolerance was restored in 46 cases ( group A), but not restored in 67 cases (group B). Compared with group B,the patients of group A were younger and had shorter course of diabetes and lower body mass index (BMI,P＜0.05); Homeostasis model assessment for β-cell function (HOMA-β) and earlyphase insulin secretion in group A were better than those of group B before and after treatment respectively (P＜0. 05 ) ,while homeostasis model assessment for insulin resistance ( HOMA-IR )in group A was lower than that of group B before treatment (P＜0. 05 ). In conclusions, rosiglitazone improved insulin resistance of type 2 diabetes patients, thus facilitated restoration of β-cells function and glucose tolerance. The related factors of glucose tolerance restoration included age ,diabetes duration, BMI, HbA1 c, β-cells function, and insulin resistance.