Pharmacodynamics of remifentanil required to prevent laryngeal mask airway insertion response in patients anesthetized with propofol by TCI
10.3760/cma.j.issn.0254-1416.2010.09.022
- VernacularTitle:靶控输注异丙酚时瑞芬太尼抑制患者喉罩置管反应的药效学
- Author:
Yang XIE
;
Hong XIE
;
Zhiyuan FANG
;
Jianhua ZHAO
- Publication Type:Journal Article
- Keywords:
Piperidines;
Propofol;
Laryngeal masks;
Dose-response relationship,drug;
Drug delivery systems
- From:
Chinese Journal of Anesthesiology
2010;30(9):1094-1095
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the pharmacodynamics of remifentanil required to prevent laryngeal mask airway (LMA) insertion response in patients anesthetized with propofol by TCI. Methods Thirty-six ASA Ⅰor Ⅱ patients aged 18-59 yr with body mass index ＜ 30 kg/m2 undergoing elective breast operation were enrolled in the study. Propofol was administered by TCI at an effect-site concentration of 4.0 μg/ml. When the patients lost conciousness, TCI of remifentanil was started. The initial target plasma concentration of remifentanil was set at 2.9 ng/ml, and the ratio of two consecutive effect-site concentrations was 1.2. LMA was inserted at 3 min after the target effect-site concentration and the plasma concentration achieved the balance. Criteria of successful insertion were defined as Muzi score≤2 and the increase in MAP and HR≤ 15% of the baseline values within 3 min after insertion. EC50 was determined by modified Dixon's up-and-down sequential trial and the 95 % confidence interval was calculated. Results The EC50 of remifentanil was 2.75 ng/ml. The 95% confidence interval was 2.51-3.01 ng/ml. Conclusion The EC50 of remifentanil for suppression of cardiovascular response to LMA insertion is 2.75 ng/ml in patients anesthetized with propofol by TCI.
