Expressions of EphA2 and EphrinA1 in bladder carcinomas and their clinical significance

VernacularTitle:EphA2、EphrinA 1在膀胱癌组织中的表达及其临床意义
Author: Jinqing WANG ; Yubin ZHAO ; Shaohua ZHANG ; Feng LIU
Publication Type:Journal Article
Keywords: Urinary bladder neoplasms; Immunohistochemistry; Receptor,EphA2; EphrinA1
From: Chinese Journal of Postgraduates of Medicine 2010;33(35):25-27
CountryChina
Language:Chinese
Abstract: Objective To investigate the expressions of EphA2 and EphrinA1 in bladder carcinomas and their clinical significance. Method The expressions of EphA2 and EphrinA1 were detected on bladder carcinomas (75 cases ) by immunohistochemistry S-P method. Results ( 1 ) The positive rates of expression of EphA2 and EphrinA1 were 61.3%(46/75) and 46.7%(35/75) respectively. (2) The expression of EphA2 was related to tumor size, lymphatic metastasis and TNM staging(P＜ 0.05),but not to gender,age and pathology type (P ＞ 0.05 ). ( 3 )The expression of EphrinA1 was related to tumor size and lymphatic metastasis (P ＜ 0.05 ), but not to gender, age, pathology type and TNM staging (P ＞ 0.05 ). (4)There was significantly positive correlation between the expression of EphA2 and EphrinA1 (P ＜ 0.05).Conclusions EphA2 and EphrinA1 are related to the occurrence and development of bladder carcinoma.The combined detection of EphA2 and EphrinA1 can help to predict the clinical and pathologic characteristics of bladder carcinoma. It is an important index to assist treatment, they are predictive factors for bladder carcinoma.