Research progress of DcR3 in common malignant tumor tissues of digestive system
10.3760/cma.j.issn.1673-4203.2010.12.012
- VernacularTitle:DcR3在消化系统常见恶性肿瘤的研究进展
- Author:
Qingfeng YUE
;
Ming XIANG
;
Fangming LI
- Publication Type:Journal Article
- Keywords:
Decoy receptor 3;
Review;
Digestive system neoplasms;
Apoptosis
- From:
International Journal of Surgery
2010;37(12):826-829
- CountryChina
- Language:Chinese
-
Abstract:
Decoy receptor 3 (DcR3) is a newly discovered member of the tumor necrosis factor receptor (TNFR) superfamily, expresses highly in the digestive system neoplasms. DcR3 inhibits cellular apoptosis and produces cellular modulation by competitively combining with FasL, LIGHT and TL1A, therefore it deeply relates to the digestive system neophlasm's generation and progression. DcR3 is supposed to be the new tumor-specific marker that may cast the light to the digestive system neoplasms' generation, diagnosis,treatment, prognosis and effect observation. DcR3 is expected to open a new chapter in clinical application.
