Research progress of chemokines in dendritic cell tumor vaccines
10.3760/cma.j.issn.1673-4203.2010.12.017
- VernacularTitle:趋化因子在树突状细胞肿瘤疫苗研究中的进展
- Author:
Liangxian JIANG
;
Tienan BI
;
Shenkang ZHOU
;
Guang TAN
- Publication Type:Journal Article
- Keywords:
Chemokine;
Dendritic cell;
Tumor vaccine
- From:
International Journal of Surgery
2010;37(12):843-846
- CountryChina
- Language:Chinese
-
Abstract:
Chemokine can regulate the immuue cells migration, play the function by combining chemokine receptor. Dendritic cells(DC) are the most important professional antigen presenting cells, and their main application is prepared into a variety of cancer vaccine. Dendritic cells need to migrate while completing the functions, are related with chemokine and chemokine receptor. Chemokines always playe a regulating, promoting or inhibiting role in the processing of completing the functions and migration. So DC can present antigens, activate the initial T cells, cause immune response and kill the tumor cells and inflammatory molecules.
