The outcome of monoclonal gammopathy of undetermined significance in elderly patients

VernacularTitle:老年人意义未明的单克隆免疫球蛋白血症的转归
Author: Haifei WANG ; Naibai CHANG ; Weiliang WANG ; Hong SHI ; Baoli XING ; Shangyong NING ; Lei PEI ; Xiaodong XU
Publication Type:Journal Article
Keywords: Monoclonal gammopathies,benign; Multiple myeloma
From: Chinese Journal of Geriatrics 2010;29(12):989-991
CountryChina
Language:Chinese
Abstract: Objective To explore the outcome of monoclonal gammopathy of undetermined significance (MGUS). Methods The data from 14 MGUS patients in our hospital including clinical features, outcome and change of M protein concentration were analyzed retrospectively. Results The MGUS didn't have the clinical manifestations of multiple myeloma (MM), the time of outcome from MGUS to MM was about 4-20 years (mean time, 10 years). The most types of MM were IgA and IgG, 6 cases were IgA type, 6 cases were IgG type and 2 cases were light chain type. The concentration of immune globulin in general showed an upward trend year by year. A few showed fold lines ascend. Conclusions The elevated monoclonal immunoglobulin may develop into MM after many years. We must follow up frequently to avoid error diagnosis and missed diagnosis.