Expression and clinical implications of RADIL gene in pancreatic cancer

VernacularTitle:RADIL基因在胰腺癌组织中的表达及其临床意义
Author: Haojie HUANG ; Jun GAO ; Yiqi DU ; Yanfang GONG ; Shunli LV ; Xiaowei WANG ; Aiping XU ; Fei GAO ; Zhaoshen LI
Publication Type:Journal Article
Keywords: Pancreatic neoplasms; Small GTP binding proteins; Fluorescent quantitative PCR; RADIL genes
From: Chinese Journal of Pancreatology 2010;10(6):424-426
CountryChina
Language:Chinese
Abstract: Objective To investigate the RADIL mRNA expression in pancreatic carcinoma and to evaluate its clinical significance.Methods Fluoesecent quantitative PCR (FQ-PCR) was used to detect the RADIL mRNA expression in 40 patients with pancreatic carcinoma and adjacent tissue and in 5 healthy adult with normal pancreatic tissue and to observe its relationship with clinicopathologic parameters.Results RADIL mRNA was expressed in pancreatic carcinoma and adjacent tissue, as well as normal pancreatic tissue, and the relative expression was 2.263 ± 3.826, 5.425 ± 8.858 and 8.559 ± 4.214, respectively.There was statistically significant difference among the three groups (P ＜0.05 ).RADIL mRNA expression was closely related with the metastasis and differentiation grade ( r = -0.312 and -0.294, P ＜ 0.05 ), however, it was not significantly related to tumor site, tumor size, CA19-9, TNM staging, sex and age.Conclusions RADIL gene may have an inhibitory effect on the pancreatic cancer.