Capillary embolism is the main cause of grafts necrosis in a vascularized skin flap allotransplantation model in rats

VernacularTitle:大鼠异体皮瓣移植后不用免疫抑制剂情况下移植物坏死的主要原因
Author: Bo XIAO ; Jin ZHANG ; Bei LIU ; Shuzhong GUO
Publication Type:Journal Article
Keywords: Skin transplantation; Immunosuppressive agents; Graft rejection; Embolization
From: Chinese Journal of Organ Transplantation 2010;31(12):724-727
CountryChina
Language:Chinese
Abstract: Objective To understand acute rejection differences between untreated recipients and rapmycin-treated recipients in a rat free flap allotransplantation model. Methods Brown groin free flaps were transplanted to Lewis recipients. In the treated group, recipients were treated with rapamycin at the dose of 4 mg/kg every day from day 0 to day 14 after transplantation. In the untreated group, recipients didn't receive any treatment. Allografts were evaluated clinically and histologically. Results Allografts in the treated group showed epidermolysis as sign of rejection.Rejection sign of untreated grafts was ischemic necrosis of whole skin. In histological evaluation, the treated grafts showed "band-like" lymphocytes infiltration in the upper dermis when rejection occurred, while the untreated grafts showed thrombosis in the subdermal vessels. Conclusion The differences between the two groups implied that embolization may be responsible for the rejection of free flap allotransplantation in rat model.