Effect of trimetazidine in ischemic cardiomyopathy patients with impaired systolic function

VernacularTitle:曲美他嗪对缺血性心肌病收缩功能不全患者的疗效观察
Author: Hongying CHEN ; Xuewei CHANG
Publication Type:Journal Article
Keywords: Ischemic cardiomyopathy; Trimetazidine; Brain natriuretic peptide; Laft ventricular ejection fraction; Left ventricular end-diastolic dimension
From: Clinical Medicine of China 2010;26(12):1282-1284
CountryChina
Language:Chinese
Abstract: Objective To evaluate the effect of trimetazidine in ischemic cardiomyopathy patients with impaired systolic function. Methods There were 90 cases in total, and were divided into two groups randomly: 42patients took conventional therapy,and 48 patients took trimetazidine additionally. Plasma levels of brain natriuretic peptide (BNP), left ventricular ejection fraction(LVEF) and left ventricular end-diastolic dimension(LVEDD) were measured before and after trimetazidine therapy at 6 months, 12 months. Results Compared to conventional therapy group, LVEF, LVEDD and BNP were significantly improved in the trimetazidine group (P ＜ 0.01 ). Conclusions Trimetazidine additional to conventional therapy might improve heart function and reverse ventricles reconstitution in ischemic cardiomyopathy patients with impaired systolic function.