Toll-like receptor 4 signal transduction pathway and its role in ischemic stroke
10.3760/cma.j.issn.1673-4165.2010.010.013
- VernacularTitle:Toll样受体4信号转导通路及其在缺血性卒中中的作用
- Author:
Dong WANG
;
Zhiyong YANG
;
Hua LU
- Publication Type:Journal Article
- Keywords:
Toll-like receptor 4;
Stroke;
Brain ischemia;
Inflammation;
gene polymorphism
- From:
International Journal of Cerebrovascular Diseases
2010;18(10):777-781
- CountryChina
- Language:Chinese
-
Abstract:
Patients with ischemic stroke is often accompanied by inflammtory response. Studies have suggested that toll-like receptor 4 (TLR4) has induced the occurrence,development and of ischemic stroke and secondary brain injury. This article reviews the toil-like receptor 4 signal transduction pathway and its roles in ischemic stroke in order to provide certain basis for the development of TLR4-targeted medication.
