Influence of glucose-lowering rate on left ventricular function in type 2 diabetes mellitus patients with coronary heart disease
10.3760/cma.j.issn.1000-6699.2010.12.010
- VernacularTitle:降糖速率对2型糖尿病合并冠心病患者左心功能影响
- Author:
Zhenjie SUN
;
Weihua WU
;
Mingli WANG
;
Wei DENG
;
Lei YANG
;
Lifang SUN
;
Jiajing MIAO
;
Zhaohui ZHENG
;
Ruifeng XUE
;
Jinwei HUANG
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Coronary disease;
Left ventricular function;
Glucose-lowering rate
- From:
Chinese Journal of Endocrinology and Metabolism
2010;26(12):1050-1053
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influence of glucose-lowering rate on left ventricular function in patients with type 2 diabetes mellitus (T2DM). Methods One hundred and thirty-two cases of type 2 diabetes mellitus and 135 cases of type 2 diabetes mellitus with coronary heart disease (T2DM+CHD)received intensive glucose lowering therapy. Then, after measuring left ventricular ejection fraction (LVEF) and E/A ratio, the variation was analyzed. Results LVEF was significantly higher than that before intensive therapy in T2DMsubgroup with glucose-lowering rate less than 6 m mol · L-1 · d-1( P＜0.05 ). So was T2DM+CHD subgroup with glucose-lowering rate less than 4 mmol· L-1 · d-1 (P＜0.05). LVEF was significantly lower than that before intensive therapy in T2DM+CHD subgroup with glucose-lowering rate greater than 4 mmol · L-1 · d-1( P＜0. 05 ),while by the end of following up for 3 months, LVEF stepped up and no significant difference was observed between subgroups ( P ＞ 0. 05 ). The E/A ratio stepped up in both subgroups after intensive therapy ( P ＜ 0. 05 ).Conclusions For T2DM patients with coronary heart disease, excessively fast glucose-lowering rate may impair left ventricular function. Long-term good control of blood glucose restores the impaired left ventricular function causes by excessively fast glucose-lowering rate. After intensive therapy, left ventricular diastolic function finally improves in both subgroups regardless of the glucose-lowering rate and coronary heart disease.
