Large-scale Genotyping and Genetic Mapping in Plasmodium Parasites.
- Author:
Xin Zhuan SU
1
;
Hongying JIANG
;
Ming YI
;
Jianbing MU
;
Robert M STEPHENS
Author Information
- Publication Type:Review ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural
- Keywords: Plasmodium; malaria; phenotype; genotype; microsatellite; SNP
- MeSH: Animals; *Chromosome Mapping; DNA, Protozoan/*genetics; Gene Dosage; *Microarray Analysis; Plasmodium falciparum/*genetics; Polymorphism, Genetic
- From:The Korean Journal of Parasitology 2009;47(2):83-91
- CountryRepublic of Korea
- Language:English
- Abstract: The completion of many malaria parasite genomes provides great opportunities for genomewide characterization of gene expression and high-throughput genotyping. Substantial progress in malaria genomics and genotyping has been made recently, particularly the development of various microarray platforms for large-scale characterization of the Plasmodium falciparum genome. Microarray has been used for gene expression analysis, detection of single nucleotide polymorphism (SNP) and copy number variation (CNV), characterization of chromatin modifications, and other applications. Here we discuss some recent advances in genetic mapping and genomic studies of malaria parasites, focusing on the use of high-throughput arrays for the detection of SNP and CNV in the P. falciparum genome. Strategies for genetic mapping of malaria traits are also discussed.
